Hepatocyte growth factor in renal failure: Promise and reality
نویسندگان
چکیده
منابع مشابه
Hepatocyte growth factor prevents acute renal failure and accelerates renal regeneration in mice.
Although acute renal failure is encountered with administration of nephrotoxic drugs, ischemia, or unilateral nephrectomy, there has been no effective drug which can be used in case of acute renal failure. Hepatocyte growth factor (HGF) is a potent hepatotropic factor for liver regeneration and is known to have mitogenic, motogenic, and morphogenic activities for various epithelial cells, inclu...
متن کاملHigh concentration but low biological activity of hepatocyte growth factor in patients with chronic renal failure
Hepatocyte growth factor (HGF) is a renotropic, antifibrotic and regenerative factor with cytoprotective effects that is produced by mesenchymal cells and shows high affinity to components of extra cellular matrix, such as heparan sulphate proteoglycan (HSPG), in healthy. Patients with chronic renal failure (CRF) suffer from a chronic inflammatory disorder. In order to assess the underlying mec...
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BACKGROUND Hepatocyte growth factor (HGF) counteracts peritoneal fibrosis in animal models and in-vitro studies, but no study explored effluent HGF in peritoneal dialysis (PD) patients with ultrafiltration failure (UFF). Our aim was to assess the relationship between effluent HGF with UF profile, free water transport (FWT) and small-solute transport. METHODS We performed 4-hour, 3.86% PET wit...
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Chronic renal failure patients receiving haemodialysis and continuous ambulatory peritoneal dialysis often encounter inflammation troubles during long-period treatment. Patients with type 2 diabetes induce different degree chronic renal failure and represent low quality of life. Type 2 diabetes may be one of the most important arch-criminal factors that aggravate syndrome and renal insufficienc...
متن کاملGene transfer of hepatocyte growth factor attenuates postinfarction heart failure.
BACKGROUND Despite advances in surgical and percutaneous coronary revascularization, ongoing ischemia that is not amenable to standard revascularization techniques is a major cause of morbidity and mortality. Hepatocyte Growth Factor (HGF) has potent angiogenic and anti-apoptotic activities, and this study evaluated the functional and biochemical effects of HGF gene transfer in a rat model of p...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2000
ISSN: 0085-2538
DOI: 10.1046/j.1523-1755.2000.00987.x